The first report of a known 4A syndrome patient with suspected manifestations of COVID-19, what was the final outcome?

The present study was performed on a 24-year-old Iranian man referred to Hospital with suspected symptoms of COVID-19, including fever, weakness, and cough. According to medical history, he had Alacrima, esophageal Achalasia, and adrenal insufficiency from childhood. Based on medical records and clinical examinations, the physician suspected 3A syndrome in the patient and requested further examination for MRI, CXR, and COVID-19 RT-PCR test. The result of the COVID-19 RT-PCR test was negative the next day. The patient's CXR showed ground-glass opacity (GGO) and pulmonary fibrosis. Based on images and MRI reports, severe posterior cortical atrophy disproportionate to chronological age and bilateral atrophy of the lacrimal gland were reported. After reviewing and summarizing the records, history, examinations, and Paraclinical tests, the patient was identified as a case of 4A syndrome.

COVID-19 and papular manifestations pattern in 3 patients: a retrospective case series

COVID-19 can be associated with varying degrees of cutaneous lesions. Although these manifestations were rare, they can be considered as a specific symptom of COVID-19. Here, we present 3 patients for whom the diagnosis of COVID-19 was made by RT-PCR and a few days after the onset of systemic symptoms, papular cutaneous lesions appeared and on average after 6 days, the lesions started to disappear without any specific treatments. Demographic and clinical features of the 3 patients are summarized in Table 1.